1. Key Properties
Endogenous Metabolite Properties: It is a normal downstream product of niacin metabolism in the human body, primarily produced by nicotinamide N-methyltransferase (NNMT).
2. Biological Activity
– 1. Key Properties
Endogenous Metabolite Properties: It is a normal downstream product of niacin metabolism in the human body, primarily produced by nicotinamide N-methyltransferase (NNMT).
2. Biological Activity
– Antithrombotic Effect: This effect may be exerted through direct action on the endothelium. It also exerts vasodilation by increasing nitric oxide (NO) bioavailability and reducing endothelial nitric oxide synthase (eNOS)-dependent oxidative stress, thereby inhibiting thrombosis.
– Anti-inflammatory Effect: In vitro studies have shown that 1-methylnicotinamide chloride exhibits anti-inflammatory activity in endothelial cells at concentrations of 0.05-0.2 μM for 1-24 hours.
– Potential Effects on Cancer: Enhanced NNMT activity is a hallmark of various cancers. The direct involvement of 1-methylnicotinamide chloride in tumorigenesis associated with NNMT overexpression is under investigation. In SH-SY5Y neuroblastoma cells, which do not produce NNMT, it increases mitochondrial complex I activity and enhances cancer cell viability. It also promotes tumor angiogenesis and significantly increases the production of prostacyclin (PGI₂).
3. Applications
– Research: It is an important reagent in scientific research, used to study its metabolic pathways, physiological functions, and associations with diseases. It has applications in research projects across a wide range of fields, including healthcare, chemical engineering, biotechnology, and pharmaceuticals/biopharmaceuticals.
– Cosmetics: As a synthetic derivative of niacinamide, it possesses excellent skin conditioning and protective properties. Scientific research has validated its use in the cosmetics industry, where it can be used in skincare formulations to enhance its skincare benefits. Effect: This effect may be exerted through direct action on the endothelium. It also exerts vasodilation by increasing nitric oxide (NO) bioavailability and reducing endothelial nitric oxide synthase (eNOS)-dependent oxidative stress, thereby inhibiting thrombosis.
– Anti-inflammatory Effect: In vitro studies have shown that 1-methylnicotinamide chloride exhibits anti-inflammatory activity in endothelial cells at concentrations of 0.05-0.2 μM for 1-24 hours.
– Potential Effects on Cancer: Enhanced NNMT activity is a hallmark of various cancers. The direct involvement of 1-methylnicotinamide chloride in tumorigenesis associated with NNMT overexpression is under investigation. In SH-SY5Y neuroblastoma cells, which do not produce NNMT, it increases mitochondrial complex I activity and enhances cancer cell viability. It also promotes tumor angiogenesis and significantly increases the production of prostacyclin (PGI₂).
3. Applications
– Research: It is an important reagent in scientific research, used to study its metabolic pathways, physiological functions, and associations with diseases. It has applications in research projects across a wide range of fields, including healthcare, chemical engineering, biotechnology, and pharmaceuticals/biopharmaceuticals.
– Cosmetics: As a synthetic derivative of niacinamide, it possesses excellent skin conditioning and protective properties. Scientific research has validated its use in the cosmetics industry, where it can be used in skincare formulations to enhance its skincare benefits.
